PVC particles are spherical polymer microspheres or nanoparticles composed of polyvinyl chloride. The chlorine atoms along the PVC backbone impart chemical resistance to acids, alkalis, and organic solvents, along with thermal stability, mechanical strength, and electrical insulation. High-quality PVC microspheres exhibit monodispersity with polydispersity indices as low as 5%, ensuring consistent performance in assays and calibration. Their optical clarity and low aggregation further enhance utility in imaging and detection platforms.
Key Properties of PVC Particles
Chemical Resistance and Stability
PVC particles exhibit superior chemical stability and can withstand demanding environments, including up to 7 keV electron beam irradiation. They resist degradation by acids, alkalis, and many organic solvents, making them suitable for applications where other polymer particles might fail.
Mechanical Strength and Durability
PVC microspheres offer good mechanical strength and durability with a high elastic modulus. This physical robustness enables their use in applications requiring particles that maintain structural integrity under stress, such as in composite materials or filtration media.
Thermal and Electrical Properties
PVC particles demonstrate high-temperature resistance and electrical insulation properties. These characteristics make them suitable for industrial applications where thermal or electrical performance is important.
Optical Properties
PVC particles exhibit optical clarity and can be manufactured as plain, dyed, or fluorescent variants. This optical versatility supports applications in fluorescence microscopy, imaging, and diagnostic assays.
Surface Functionalization
Bare PVC particles are chemically inert. Surface functionalization—the introduction of reactive chemical groups or biological ligands onto the particle surface—transforms them from passive carriers into active platforms for biomolecule conjugation.
BOT Bioparticles offers a comprehensive range of surface-functionalized PVC particles:
Functional Group | Application |
Carboxyl (-COOH) | Covalent coupling to amine-containing biomolecules via EDC/NHS chemistry |
Amino (-NH₂) | Conjugation to carboxyl-containing molecules or glutaraldehyde-mediated protein binding |
Biotin | High-affinity capture of streptavidin-conjugated probes |
Streptavidin | Binding of biotinylated antibodies, nucleic acids, or other ligands |
Protein A / Protein G | Oriented immobilization of antibodies via Fc region binding |
Avidin | Strong specific binding affinity for biotinylated targets |
Through surface modification, PVC particles can achieve precise biomedical functions such as drug delivery, immunoassay, and biomolecular separation.
Biomedical Applications
PVC particles are versatile polymer microspheres widely used in biomedicine and industry. In drug delivery, functionalized particles (e.g., avidin- or carboxyl-modified) enable targeted delivery and enhanced sensitivity. They serve as solid supports in diagnostic immunoassays and biosensing, while fluorescent variants support cell labeling, tracking, and microscopy. Good biocompatibility also makes them suitable for tissue engineering scaffolds and cell culture, and their monodispersity ensures reliable flow cytometry calibration. Industrially, they act as coating additives, filtration media, composite fillers, and fluorescent tracers for environmental monitoring. Safety studies indicate that PVC particles can induce cytotoxicity and inflammatory responses under certain conditions, highlighting the need for careful handling. All BOT Bioparticles PVC products are intended for laboratory research use only, not for clinical or therapeutic applications.
How to Buy?
BOT Bioparticles offers a comprehensive range of high-quality PVC particles:
PVC Particles
Functional Group | ||||
100% PVC Particles
Functional Group | ||||